Product Introduction
| 3-Cyanopyridine Basic information |
| Product Name: | 3-Cyanopyridine |
| Synonyms: | NICOTINIC ACID NITRILE;NICOTINONITRILE;NICOTINE ACID NITRILE;SPECS AC-907/25014098;TIMTEC-BB SBB007554;IFLAB-BB F2108-0102;BETA-CYANOPYRIDINE;3-Azabenzonitrile |
| CAS: | 100-54-9 |
| MF: | C6H4N2 |
| MW: | 104.11 |
| EINECS: | 202-863-0 |
| Product Categories: | Pharmaceutical intermediates;Pyridines derivates;Heterocyclic Compounds;bc0001 |
| Mol File: | 100-54-9.mol |
 |
|
| 3-Cyanopyridine Chemical Properties |
| Melting point | 48-52 °C(lit.) |
| Boiling point | 201 °C(lit.) |
| density | 1.159 |
| refractive index | 1.5242 (estimate) |
| Fp | 184 °F |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | 140g/l |
| form | Crystalline Mass, Crystals or Chunks |
| pka | pK1:1.45(+1) (25°C) |
| color | Colorless or white to yellow |
| Water Solubility | 140 g/L (20 ºC) |
| BRN | 107711 |
| Exposure limits | NIOSH: IDLH 25 mg/m3 |
| Stability: | Incompatible with strong oxidizing agents, strong reducing agents, strong acids, strong bases. |
| InChIKey | GZPHSAQLYPIAIN-UHFFFAOYSA-N |
| CAS DataBase Reference | 100-54-9(CAS DataBase Reference) |
| NIST Chemistry Reference | 3-Pyridinecarbonitrile(100-54-9) |
| EPA Substance Registry System | 3-Pyridinecarbonitrile (100-54-9) |
| Safety Information |
| Hazard Codes | Xn |
| Risk Statements | 22-36/37/38 |
| Safety Statements | 22-24/25-36/37/39-26 |
| WGK Germany | 3 |
| RTECS | QT3030000 |
| TSCA | Yes |
| HS Code | 29333999 |
| Hazardous Substances Data | 100-54-9(Hazardous Substances Data) |
| MSDS Information |
| Provider | Language |
|---|---|
| 3-Cyanopyridine | English |
| SigmaAldrich | English |
| ACROS | English |
| ALFA | English |
| 3-Cyanopyridine Usage And Synthesis |
| Chemical Properties | white to beige solid |
| Chemical Properties | The cyanopyridines are as follows: 2-cyano-: A white to tan liquid or solid. Almond odor. Boiling point=2213℃ ; freezing/melting point=27℃ ; flash point=89℃ . 3-cyano-: a colorless liquid or gray crystal- line solid. |
| Uses | 3-Cyanopyridine is used in the preparation of arylthiazolines and arylimidazolines via dibromodimethylhydantoin-catalyzed condensation of aryl nitriles with ethylene diamine or aminoethanethiol. |
| Definition | ChEBI: A nitrile that is pyridine substituted by a cyano group at position 3. |
| Synthesis Reference(s) | Tetrahedron Letters, 29, p. 2155, 1988 DOI: 10.1016/S0040-4039(00)86697-6 |
| Potential Exposure | Limits in Air NIOSH IDLH525 mg/m3 NIOSH REL: (nitriles) 2 ppm, Ceiling Concentration, not to be exceeded in any 15-minute work period. |
| Shipping | UN3276 Nitriles, liquid, toxic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required, Potential Inhalation Hazard (Special Provision 5). |
| Purification Methods | It is recrystallised to constant melting point from o-xylene/hexane. [Beilstein 22/2 V 115.] |
| Incompatibilities | Oxidizing agents, such as perchlorates, peroxides, and permanganates. Nitriles may polymerize in the presence of metals and some metal compounds. They are incompatible with acids; mixing nitriles with strong oxidizing acids can lead to extremely violent reactions. Nitriles are generally incompatible with other oxidizing agents such as peroxides and epoxides. The combination of bases and nitriles can produce hydrogen cyanide. Nitriles are hydrolyzed in both aqueous acid and base to give car- boxylic acids (or salts of carboxylic acids). These reactions generate heat. Peroxides convert nitriles to amides. Nitriles can react vigorously with reducing agents. Acetonitrile and propionitrile are soluble in water, but nitriles higher than propionitrile have low aqueous solubility. They are also insoluble in aqueous acids . |
| 3-Cyanopyridine Preparation Products And Raw materials |
| Raw materials | 4-Chlorobenzaldehyde-->Nicotinamide-->N-PHENYL-1-NAPHTHYLAMINE HYDROBROMIDE |
| Preparation Products | Nicotinic acid-->Nicotinamide-->3-(AMINOMETHYL)PYRIDINE-->2-(3-PYRIDYL)-1,3-THIAZOLE-4-CARBOXYLIC ACID-->2-chloro-5-cyanopyridine-->3-Pyridinecarboxaldehyde-->2-(2-PYRIDINYL)-4-(TRIFLUOROMETHYL)-5-PYRIMIDINECARBOXYLIC ACID-->3-AMINOMETHYL-PYRIDINE-2-CARBOXYLIC ACID-->3-AMIDINOPYRIDINIUM CHLORIDE-->ETHYL 4-(TRIFLUOROMETHYL)-2-(PYRIDIN-2-YL)PYRIMIDINE-5-CARBOXYLATE-->3-(TERT-BUTOXYCARBONYLAMINO-METHYL)-PYRIDINE-2-CARBOXYLIC ACID-->3,3'-DIPICOLYLAMINE-->3-PYRIDINECARBOXAMIDINE-->3-CYANOPYRIDIN-4-YLBORONIC ACID-->3-[(N-(TERT-BUTYLOXYCARBONYL)AMINO)METHYL]PYRIDINE-->3-(Aminomethyl)pyridine-->3-PYRIDYLAMIDOXIME-->Methyl 2-(3-cyanopyridin-4-yl)acetate-->3-Pyridinemethanol-->Benzyltriphenylphosphonium chloride |
Hot Tags: 3-cyanopyridine, China 3-cyanopyridine manufacturers, suppliers, factory, Tri-functional, Di-functional, 2 Phenoxyethyl Acrylate, Neopentyl Glycol Diacrylate, CAS 57472 68 1, Reative Monomers
Previous: 2-Chloronicotinic Acid
Next: 3-Picoline
You Might Also Like
Send Inquiry
