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Trans-4-Dimethylaminocrotonic Acid Hydrochloride

Product Introduction

trans-4-Dimethylaminocrotonic acid hydrochloride Basic information

Product Name:	trans-4-Dimethylaminocrotonic acid hydrochloride
Synonyms:	2E)-4-(Dimethylamino)-2-butenoic acid hydrochloride;Afatinib int-2 Trans-4-Dimethylaminocrotonic acid hydrochloride;2-Butenoic acid, 4-(dimethylamino)-, (2E)-, hydrochloride;trans-4-Dimethylaminocrotonic acid hydrochloride, >=97%;trans-4-Dimethylaminocrotonic;trans-4-dimethylaminocrotonic acid hydrochloride salt;2-Butenoic acid,4-(dimethylamino)-, hydrochloride (1:1), (2E)-;trans-4-Dimethylaminocrotonic acid hydrochloride(848133-35-7)
CAS:	848133-35-7
MF:	C6H12ClNO2
MW:	165.62
EINECS:	617-631-8
Product Categories:	Others chemical reagents;Amines;Intermediates & Fine Chemicals;Pharmaceuticals;848133-35-7
Mol File:	848133-35-7.mol

trans-4-Dimethylaminocrotonic acid hydrochloride Chemical Properties

Melting point	162 °C
storage temp.	Inert atmosphere,Room Temperature
solubility	DMSO (Slightly), Methanol (Slightly), Water (Slightly)
form	Solid
color	White to Off-White
InChI	InChI=1S/C6H11NO2.ClH/c1-7(2)5-3-4-6(8)9;/h3-4H,5H2,1-2H3,(H,8,9);1H/b4-3+;
InChIKey	UUHNQHFOIVLAQX-BJILWQEISA-N
SMILES	C(/CN(C)C)=C\C(=O)O.Cl
CAS DataBase Reference	848133-35-7(CAS DataBase Reference)

Safety Information

HS Code

2922498590

MSDS Information

trans-4-Dimethylaminocrotonic acid hydrochloride Usage And Synthesis

Description	trans-4-Dimethylaminocrotonic acid hydrochloride is a very important pharmaceutical intermediate and is an essential part of the structure of the anti-tumour drugs afatinib and neratinib. It is also an important organic synthesis reagent for the preparation of novel pyrazole derivatives and 6-heterocycloalkyl quinazoline derivatives.
Chemical Properties	White Solid
Uses	trans 4-Dimethylaminocrotonic acid HCl is a reagent used in the preparation of tyrosine kinase inhibiting antitumor agents.
Synthesis	trans-4-Dimethylaminocrotonic acid hydrochloride is synthesised using (E)-4-(dimethylamino)-2-butenoic acid methyl ester as a raw material by adding reagents such as water, sodium hydroxide, methanol, and hydrogen chloride through a chemical reaction.

trans-4-Dimethylaminocrotonic acid hydrochloride Preparation Products And Raw materials

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