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3-Methylamino-1,2-propanediol

Product Introduction

3-Methylamino-1,2-propanediol Basic information

Product Name:	3-Methylamino-1,2-propanediol
Synonyms:	N-METHYL-3-AMINO-1,2-PROPANEDIOL;3-(AMINOMETHYL)-1,2-PROPANEDIOL;3-METHYLAMINO-PROPANE-1,2-DIOL;3-METHYLAMINO-1,2-PROPANEDIOL;2,3-Dihydroxy-N-methylpropylamine;3-Methylamino-1,2-Propandiol;N-Methyl-2,3-dihydroxypropylamine;1,2-Propanediol, 3-(methylamino)-
CAS:	40137-22-2
MF:	C4H11NO2
MW:	105.14
EINECS:	254-809-0
Product Categories:	Amino Alcohols;Organic Building Blocks;API;Oxygen Compounds;bc0001;40137-22-2
Mol File:	40137-22-2.mol

3-Methylamino-1,2-propanediol Chemical Properties

Melting point	69°C (estimate)
Boiling point	247 °C
density	1.095 g/mL at 20 °C(lit.)
refractive index	n20/D 1.476
Fp	152 °C
storage temp.	Inert atmosphere,Room Temperature
form	clear liquid
pka	14.09±0.20(Predicted)
color	Colorless to Almost colorless
Specific Gravity	1.0921
PH	11.5 (100g/l, H2O, 20℃)
Water Solubility	miscible
BRN	1733341
CAS DataBase Reference	40137-22-2(CAS DataBase Reference)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36-37/39
RIDADR	2735
WGK Germany	3
F	3-10-34
HazardClass	8
PackingGroup	II
HS Code	29221980
Toxicity	LD50 orally in Rabbit: > 2000 mg/kg

MSDS Information

Provider	Language
3-Methylamino-1,2-propanediol	English
SigmaAldrich	English
ACROS	English
ALFA	English

3-Methylamino-1,2-propanediol Usage And Synthesis

Description	3-Methylamino-1,2-propanediol (MAPD) is a clear liquid with the chemical formula C₄H₁₁NO₂. It can be synthesized from allylamine and alkanolamine via a thermal process. It reacts with chloride to form methyl chloroacetate, which can then be converted into 3-methylamino-1,2-propanediol by reaction with methanol. The production process for this substance has been shown to generate low levels of hazardous substances such as polycyclic aromatic hydrocarbons (PAHs) and dioxins.
Chemical Properties	clear colorless to pale yellow viscous liquid
Uses	3-Methylamino-1,2-propanediol is a reactive compound that is used in the synthesis of organic acids. It is also used as an intermediate in the manufacture of polyethylene glycols and particle coatings.
Definition	ChEBI: 3-methylamino-1,2-propanediol is a secondary amine.
Preparation	3-Methylamino-1,2-propanediol (MAPD) is synthesized by reacting 3-chloro-1,2-propanediol (CPD) with monomethyl amine in alkaline environment by adding sodium hydroxide. Afterwards, the product undergoes a series of purification steps. N-Methyl-1-amino-2,3-propandiol (45A) Methylamine (172ml of a 40% solution in water, 2 mol) was cooled to 0 °C and 2,3-epoxy-1-propanol (25g, 0.34mol) was added at a rate to maintain the temperature at or below 10 °C. The mixture was stirred for 3 hours at 0 °C. Excess methylamine and water was evaporated in vacuo and the product was purified by distillation at 103-105 °C, at 0.5 mm Hg, to give the compound 3-Methylamino-1,2-propanediol.
Hazard	3-Methylamino-1,2-propanediol is danger. H314 (32.76%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation] H315 (67.24%): Causes skin irritation [Warning Skin corrosion/irritation] H319 (65.52%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]