Aromatic Acetophenones & Derivatives (substituted);Fluorobenzene;ketone;Adehydes, Acetals & Ketones;Fluorine Compounds;C7 to C8;Acetophenone Series;Aryl Fluorinated Building Blocks;Building Blocks;C7 to C8;C8-C12;Carbonyl Compounds;Chemical Synthesis;Fluorinated Building Blocks;Carbonyl Compounds;Ketones;Organic Building Blocks;Organic Fluorinated Building Blocks;Other Fluorinated Organic Building Blocks;11;445-27-2;pharmaceutical
Mol File:
445-27-2.mol
2'-Fluoroacetophenone Chemical Properties
Melting point
26-27C
Boiling point
187-189 °C(lit.)
density
1.137 g/mL at 20 °C(lit.)
refractive index
n20/D 1.507(lit.)
Fp
143 °F
storage temp.
Sealed in dry,Room Temperature
solubility
Soluble in Acetone, Chloroform, Dichloromethane, Ethanol, Ethyl Acetate and Methanol.
form
Liquid
Specific Gravity
1.121
color
Clear colorless to yellow
BRN
2041344
InChIKey
QMATYTFXDIWACW-UHFFFAOYSA-N
CAS DataBase Reference
445-27-2(CAS DataBase Reference)
NIST Chemistry Reference
o-Fluoroacetophenone(445-27-2)
Safety Information
Hazard Codes
Xi
Risk Statements
36/37/38
Safety Statements
26-36-37/39-37
RIDADR
1993
WGK Germany
3
HazardClass
IRRITANT
PackingGroup
III
HS Code
29147090
MSDS Information
Provider
Language
1-(2-Fluorophenyl)ethanone
English
SigmaAldrich
English
ACROS
English
ALFA
English
2'-Fluoroacetophenone Usage And Synthesis
Chemical Properties
clear colorless to light yellow or light green
Uses
2'-Fluoroacetophenone is used as starting reagent in the synthesis of ascididemin. It is used to produce 1-(2-piperidin-1-yl-phenyl)-ethanone by reaction with piperidine.
Synthesis Reference(s)
Tetrahedron Letters, 31, p. 6179, 1990 DOI: 10.1016/S0040-4039(00)97018-7
General Description
The enantioselective reduction of 2′-fluoroacetophenone has been investigated.
2'-Fluoroacetophenone Preparation Products And Raw materials
