Product Introduction
| 4-Hydroxybenzyl alcohol Basic information |
| Product Name: | 4-Hydroxybenzyl alcohol |
| Synonyms: | 4-hydroxyphenyl Methanol;4-(Hydroxymethyl)phenol 98%;4-Hydroxybenzyl alcohol, (4-Hydroxyphenyl)methanol;4-Hydroxybenzyl alcohol, 97% 25GR;The hydroxy benzyl alcohol;P-(HYDROXYMETHYL)PHENOL;P-HYDROXYBENZYL ALCOHOL;RARECHEM AL BD 0098 |
| CAS: | 623-05-2 |
| MF: | C7H8O2 |
| MW: | 124.14 |
| EINECS: | 210-768-0 |
| Product Categories: | Aromatics;Benzhydrols, Benzyl & Special Alcohols;Alphabetical Listings;Flavors and Fragrances;G-H;Bifunctional CrosslinkersOxygen Compounds;Alcohols;C7 to C8;Linkers;Peptide Synthesis;Bifunctional Crosslinkers;Peptide Chemistry;Building Blocks;C7 to C8;Chemical Biology;Chemical Synthesis;Organic Building Blocks;Oxygen Compounds;Pharmaceutical intermediates;bc0001;623-05-2 |
| Mol File: | 623-05-2.mol |
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| 4-Hydroxybenzyl alcohol Chemical Properties |
| Melting point | 114-122 °C(lit.) |
| Boiling point | 251-253°C |
| density | 1.1006 (rough estimate) |
| refractive index | 1.5035 (estimate) |
| FEMA | 3987 | 4-HYDROXYBENZYL ALCOHOL |
| Fp | 251-253°C |
| storage temp. | Store below +30°C. |
| solubility | 6.7g/l soluble |
| form | Crystalline Powder |
| pka | pK1:9.82 (25°C) |
| color | Pink to beige |
| Odor | at 100.00 %. fruity bitter almond sweet coconut |
| Odor Type | fruity |
| Water Solubility | Soluble in water (6.7 mg/ml at 20°C), dioxane (100 mg/ml), 1N NaOH (50 mg/ml), DMSO, and methanol. |
| Sensitive | Light Sensitive/Air Sensitive |
| JECFA Number | 955 |
| BRN | 1858967 |
| InChIKey | BVJSUAQZOZWCKN-UHFFFAOYSA-N |
| LogP | 0.21 |
| CAS DataBase Reference | 623-05-2(CAS DataBase Reference) |
| NIST Chemistry Reference | Benzenemethanol, 4-hydroxy-(623-05-2) |
| EPA Substance Registry System | 4-Hydroxybenzenemethanol (623-05-2) |
| Safety Information |
| Hazard Codes | Xi |
| Risk Statements | 36-36/37/38 |
| Safety Statements | 26-24/25-36 |
| WGK Germany | 3 |
| RTECS | DA4796800 |
| F | 8-9-23 |
| Hazard Note | Irritant/Keep Cold/Air Sensitive/Light Sensitive |
| HS Code | 29072900 |
| MSDS Information |
| Provider | Language |
|---|---|
| 4-hydroxybenzenemethanol | English |
| SigmaAldrich | English |
| ACROS | English |
| ALFA | English |
| 4-Hydroxybenzyl alcohol Usage And Synthesis |
| Chemical Properties | Pink to beige crystalline powder |
| Chemical Properties | 4-Hydroxybenzyl alcohol is a white crystalline powder with slightly fruity-sweet coconut odor |
| Occurrence | Reportedly found in vanilla, Bourbon (Vanilla plantifolia Andrew |
| Uses | 4-Hydroxybenzyl alcohol is also used as an important raw material and intermediate used in organic Synthesis, pharmaceuticals, agrochemicals and dyestuff. |
| Preparation | Prepared from p-cresol by using the microorganism, Pseudomonas putida. |
| Definition | ChEBI: P-hydroxybenzyl alcohol is a member of the class of benzyl alcohols that is benzyl alcohol substituted by a hydroxy group at position 4. It has been isolated from Arcangelisia gusanlung. It has a role as a plant metabolite. It is a member of phenols and a member of benzyl alcohols. |
| General Description | 4-Hydroxybenzyl alcohol (HBA) is a phenolic compound found in Gastrodia elata. It is as an antioxidant and anti-asthmatic agent. |
| Flammability and Explosibility | Not classified |
| Contact allergens | Methylol phenols are sensitizers contained in resins based on phenol and formaldehyde of the resol type. Cross-reactivity is possible with other phenol derivative molecules. |
| IC 50 | IC50 >0.2 mM (human); ALDH5A1: IC50 >1 mM (human); ABAT: IC50 >1 mM (human); Tyrosinase: IC50 >1 mM (Agaricus bisporus) |
| Purification Methods | Crystallise the alcohol from H2O, *C6H6 (m 124o), *C6H6/EtOH or ClCH2CH2Cl (m 122o). [Beilstein 6 III 4546, 6 IV 5909.] |
| 4-Hydroxybenzyl alcohol Preparation Products And Raw materials |
| Raw materials | Deferasirox-->PotassiuM triMethylacetate, 95%-->Sodium Butyrate |
| Preparation Products | 4-Hydroxybenzaldehyde-->4-(BROMOMETHYL)PHENOL-->(4-TERT-BUTOXY-PHENYL)-METHANOL-->4-(2-METHYLPROPOXY)-BENZENEMETHANAMINE-->ACETAGASTRODINE-->4-HYDROXY-3-NITROBENZYL ALCOHOL-->4-[2-(1-AZEPANYL)ETHOXY]BENZYL CHLORIDE HCL-->Phenylacetic acid-->p-(2,3-Epoxypropoxy)benzyl Alcohol-->2H-1-Benzopyran-6-Methanol, 3,4-dihydro-2-(4-Methyl-1-piperazinyl)-4-phenyl- |
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