Product Introduction
| 4'-Hydroxypropiophenone Basic information |
| Product Name: | 4'-Hydroxypropiophenone |
| Synonyms: | PARA-ETHYLKETOPHENOL;PARA-PROPIONYLPHENOL;4-HYDROXYPROPIOPHENONE / PAROXYPROPIONE;1-(4-hydroxyphenyl)propan-1-one;4''-HYDROXYPROPRIOPHENONE;4′-Hydroxypropiophen;P-acetone;4'-Hydroxypropiophenone, 97+% |
| CAS: | 70-70-2 |
| MF: | C9H10O2 |
| MW: | 150.17 |
| EINECS: | 200-743-2 |
| Product Categories: | C9;Carbonyl Compounds;Acetophenone Series;Aromatic Propiophenones (substituted);Ketones;PROFENONE;Building Blocks;Carbonyl Compounds;Chemical Synthesis;Organic Building Blocks;70-70-2 |
| Mol File: | 70-70-2.mol |
 |
|
| 4'-Hydroxypropiophenone Chemical Properties |
| Melting point | 36-38 °C(lit.) |
| Boiling point | 152-154 °C26 mm Hg(lit.) |
| density | 1.09 g/cm3 (20℃) |
| refractive index | 1.5360 (estimate) |
| FEMA | 2005 | ACETANISOLE |
| Fp | >230 °F |
| storage temp. | Store below +30°C. |
| solubility | methanol: 0.1 g/mL, clear |
| pka | 8.87±0.26(Predicted) |
| form | Solid |
| color | White |
| Water Solubility | 0.34 g/l (15 ºC) |
| Merck | 14,7044 |
| BRN | 907511 |
| LogP | 2.030 |
| CAS DataBase Reference | 70-70-2(CAS DataBase Reference) |
| NIST Chemistry Reference | 1-Propanone, 1-(4-hydroxyphenyl)-(70-70-2) |
| EPA Substance Registry System | 1-Propanone, 1-(4-hydroxyphenyl)- (70-70-2) |
| Safety Information |
| Hazard Codes | Xn,Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 37-24/25-36-26 |
| WGK Germany | 3 |
| RTECS | UH1925000 |
| TSCA | Yes |
| HS Code | 29145000 |
| Toxicity | LD50 orally in Rabbit: 11800 mg/kg |
| MSDS Information |
| Provider | Language |
|---|---|
| 4'-Hydroxypropiophenone | English |
| SigmaAldrich | English |
| ACROS | English |
| ALFA | English |
| 4'-Hydroxypropiophenone Usage And Synthesis |
| Chemical Properties | white powder |
| Uses | gonadotropic hormone inhibitor |
| Uses | p-Hydroxypropiophenone is a 4-hydroxyphenyl ketone used in the preparation of potential antitumor agents. p-Hydroxypropiophenone is a lignin degrradation product. |
| Uses | Intermediates of Liquid Crystals |
| Preparation | Preparation by Fries rearrangement of phenyl propionate with aluminium chloride in refluxing carbon disulfide ? then at 130–150° for 2–3 h after solvent elimination (45–50%) with aluminium chloride in nitrobenzene at 50° for 18 h (72%) or at ? 20° for 48 h (60%) with aluminium chloride in nitromethane at 20° for 7–8 days (80%) with aluminium chloride in chlorobenzene using microwave irradiation for ? 3 min at 106° (62%) with aluminium chloride in ethylene dichloride at 95° for 5 h or in heptane at ? 80–90° for 7 h (36%), in benzene or in tetrachloroethane at 80°; with aluminium chloride in the presence of propionyl chloride at 50–60° for ? 6 h (49%) with aluminium chloride without solvent at 50° for 10 h with titanium tetrachloride in nitromethane at 20° for 7 days (56%) or ? without solvent at 50° for 10 h (39%) with polyphosphoric acid at 100° (61%) with boron trifluoride at 50° for 3 h (46%) with stannic chloride at 50° for 3 h (10%). |
| Definition | ChEBI: P-Hydroxypropiophenone is a member of acetophenones. |
| Synthesis Reference(s) | The Journal of Organic Chemistry, 30, p. 2491, 1965 DOI: 10.1021/jo01018a528 |
| Safety Profile | Poison by intraperitoneal, subcutaneous, and parenteral routes. An experimental teratogen. Other experimental reproductive effects. A flammable liquid. When heated to decomposition it emits acrid smoke and irritating fumes. See also KETONES. |
| target | Estrogen receptor |
| Purification Methods | 4'-Hydroxypropiophenone [70-70-2] M 150.2, m 149o, b 140-145o/0.5mm, 8.05. Crystallise the phenone from H2O (m 149.8-150.2o) or EtOH (m 147o). The benzoyl derivative has m 117o, and the semicarbazone has m 183o (EtOH). [Beilstein 8 H 102, 8 II 104, 8 III 379.] |
| 4'-Hydroxypropiophenone Preparation Products And Raw materials |
| Raw materials | Carbon disulfide-->phenyl propionate-->Methoxypropiophenone-->Benzenemethanol, α-ethyl-4-hydroxy--->4-BENZYLOXYPROPIOPHENONE-->4'-Bromopropiophenone-->4-Propylphenol |
| Preparation Products | 2'-Hydroxypropiophenone-->4-Propanoylphenyl 2,2-dimethylpropanoate-->4-(4-hydroxyphenyl)-5-methyl-1,3-hiazol-2-amine-->1-(3,5-Dibromo-4-hydroxyphenyl)-1-propanone-->1-[4-(2-PIPERIDIN-1-YLETHOXY)PHENYL]PROPAN-1-ONE-->(E/Z)-1-[4-(2-Chloroethoxy)phenyl]-2-(4-hydroxyphenyl)-1-phenyl-1-butene-->1-[4-(difluoromethoxy)phenyl]propan-1-amine |
Hot Tags: 4'-hydroxypropiophenone, China 4'-hydroxypropiophenone manufacturers, suppliers, factory, Methoxypolyethylene Glycols, Mono-functional, Tetrahydrofurfuryl Acrylate, Trimethylolpropane Triacrylate, 2 Phenoxyethyl Acrylate, CAS 57472 68 1
Previous: 2,6-Dimethyl-4-hydroxybenzaldehyde
Next: 4'-Benzyloxyacetophenone
You Might Also Like
Send Inquiry
