Bis(2-chloroethyl)amine hydrochloride Basic information
Product Name:
Bis(2-chloroethyl)amine hydrochloride
Synonyms:
BIS (2-CHLOROETHYL) AMINE HCL;BIS(2-CHLOROETHYL)AMINE HYDROCHLORIDE;BIS(2-CHLOROETHYL)AMMONIUM CHLORIDE;DI-(2-CHLOROETHYL)AMINE HYDROCHLORIDE;2,2'-DICHLORODIETHYLAMINE HYDROCHLORIDE;2,2'-dichloro-diethylaminhydrochloride;2-chloro-n-(2-chloroethyl)ethanaminehydrochloride;2-chloro-n-(2-chloroethyl)-ethanaminhydrochloride
CAS:
821-48-7
MF:
C4H10Cl3N
MW:
178.49
EINECS:
212-479-5
Product Categories:
Amines, Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals;Pharmaceutical Intermediates;Amine Salts;Nitrogen Compounds;Organic Building Blocks;821-48-7
Mol File:
821-48-7.mol
Bis(2-chloroethyl)amine hydrochloride Chemical Properties
Melting point
212-214 °C(lit.)
storage temp.
Store below +30°C.
solubility
>100g/l
form
Crystalline Powder
color
White to beige
Water Solubility
SOLUBLE
Sensitive
Hygroscopic
BRN
3550356
CAS DataBase Reference
821-48-7(CAS DataBase Reference)
NIST Chemistry Reference
2,2'-Dichlorodiethylamine hydrochloride(821-48-7)
EPA Substance Registry System
Ethanamine, 2-chloro-N-(2-chloroethyl)-, hydrochloride (821-48-7)
Hazard Codes
Xi,T,C
Risk Statements
36/37/38-36-34
Safety Statements
26-45-36/37/39-27
RIDADR
2811
WGK Germany
3
RTECS
IA1225000
Hazard Note
Irritant/Toxic
TSCA
Yes
HazardClass
8
PackingGroup
III
HS Code
29211980
Toxicity
LD50 orally in Rabbit: 1150 mg/kg
Provider
Language
Bis(2-chloroethyl)amine hydrochloride
English
SigmaAldrich
English
ACROS
English
ALFA
English
Bis(2-chloroethyl)amine hydrochloride Usage And Synthesis
Chemical Properties
white to beige crystalline powder
Uses
A cytotoxic metabolite of Cyclophosphamide; a deuterated analog of Nor-nitrogen mustard.
Uses
Bis(2-chloroethyl)amine hydrochloride is used as an intermediate in chemicals synthesis and building block for piperazine derivatives.
Safety Profile
A poison by inhalation,intraperitoneal, intramuscular, and subcutaneous routes.An experimental teratogen. Human mutation datareported. When heated to decomposition it emits toxicfumes of NH3, NOx, and Cl-.
Purification Methods
Crystallise the salt from Me2CO or MeOH/Et2O. The picrate has m 112-113o (from EtOH or Me2CO). [Mann J Chem Soc 464 1934, Ward J Am Chem Soc 57 915 1935,
Bis(2-chloroethyl)amine hydrochloride Preparation Products And Raw materials
Raw materials
Diethanolamine
Preparation Products
1-CYCLOPROPYLPIPERAZINE-->(4-PHENYL-PIPERAZIN-1-YL)-ACETIC ACID-->1-AMINO-4-(2-HYDROXYETHYL)PIPERAZINE-->N-(3-Trifluoromethylphenyl)piperazine-->4-CYANO-4-PHENYLPIPERIDINE HYDROCHLORIDE-->3-(4-PHENYL-PIPERAZIN-1-YL)-PROPIONIC ACID-->1-(3-NITROPHENYL)-PIPERAZINE-->Thiomorpholine-->1-(3,5-DICHLOROPHENYL)PIPERAZINE-->1-(3-FLUOROPHENYL)PIPERAZINE-->1-(1-PHENYLETHYL)PIPERAZINE-->1-(4-Methoxyphenyl)piperazine-->1-(3-Chlorophenyl)piperazine dihydrochloride-->3-(4-methylpiperazin-1-yl)phenylboronic acid-->1-(3,4-Dichlorophenyl)piperazine-->1-(4-Methoxyphenyl)piperazine dihydrochloride-->4-(4-Methylpiperazin-1-yl)phenylboronic Acid-->1-[2-(MORPHOLIN-4-YL)-ETHYL]-PIPERAZINE-->1-(2-Methoxyphenyl)piperazine hydrobromide-->1-(3-METHYLPHENYL)PIPERAZINE-->1-(3-Methoxyphenyl)piperazine-->1-(2-FLUOROPHENYL)PIPERAZINE HYDROCHLORIDE-->1-(2-ETHOXYPHENYL)PIPERAZINE HYDROCHLORIDE-->Tert-butyl bis(2-chloroethyl)carbamate-->1-(4-Chlorophenyl)piperazine-->1-(2-Methylphenyl)piperazine-->1-(4-METHYLPHENYL)PIPERAZINE-->1-(1-NAPHTHYL)PIPERAZINE HYDROCHLORIDE-->N-(2-Methylphenyl)piperazine hydrochloride
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