Products

Home / Products/ Chemical Reagents / Organic Reagents

Tetrakis(hydroxymethyl)phosphonium Chloride

Product Introduction

Tetrakis(hydroxymethyl)phosphonium chloride Basic information

Product Name:	Tetrakis(hydroxymethyl)phosphonium chloride
Synonyms:	THPS-UPC;THPC;TETRA(HYDROXYMETHYL)PHOSPHONIUM CHLORIDE;TETRAKIS(HYDROXYMETHYL)PHOSPHONIUM CHLORIDE;tetramethylolphosphonium chloride;nci-c55061;Phosphonium,tetrakis(hydroxymethyl)-,chloride;pyrosettkc
CAS:	124-64-1
MF:	C4H12ClO4P
MW:	190.56
EINECS:	204-707-7
Product Categories:	texitile auxiliary agents;Phosphonium Compounds;Phosphonium Salts;Greener Alternatives: Catalysis;Phase Transfer Catalysts;Phosphonium Salts
Mol File:	124-64-1.mol

Tetrakis(hydroxymethyl)phosphonium chloride Chemical Properties

Melting point	154°C
Boiling point	115°C/760mmHg
density	1.341 g/mL at 25 °C
vapor pressure	0Pa at 25℃
refractive index	n20/D 1.512
form	Solution
pka	6.05[at 20 ℃]
color	Clear light pink or yellow-green
Water Solubility	>=10 g/100 mL at 20 ºC
BRN	3631669
InChI	InChI=1S/C4H12O4P.ClH/c5-1-9(2-6,3-7)4-8;/h5-8H,1-4H2;1H/q+1;/p-1
InChIKey	AKXUUJCMWZFYMV-UHFFFAOYSA-M
SMILES	[P+](CO)(CO)(CO)CO.[Cl-]
LogP	-9.8
CAS DataBase Reference	124-64-1(CAS DataBase Reference)
EPA Substance Registry System	Tetrakis(hydroxymethyl)phosphonium chloride (124-64-1)

Safety Information

Hazard Codes	T,N
Risk Statements	21-25-38-41-42/43-51/53
Safety Statements	22-26-36/37/39-45-60-61-23
RIDADR	UN 2810 6.1/PG 3
WGK Germany	3
RTECS	TA2450000
HazardClass	8
PackingGroup	III
HS Code	29319019
Hazardous Substances Data	124-64-1(Hazardous Substances Data)
Toxicity	mammal (species unspecified),LD50,oral,400mg/kg (400mg/kg),Kobunshi. High Polymers. Vol. 24, Pg. 788, 1975.

MSDS Information

Provider	Language
Tetrakis(hydroxymethyl)phosphonium chloride	English
SigmaAldrich	English

Tetrakis(hydroxymethyl)phosphonium chloride Usage And Synthesis

Chemical Properties	Clear light pink or yellow-green solution
Uses	Flame-retarding agent for cotton fabrics. May be used in combination with triethylolamine and urea (Roxel process) or with triethanolamine and tris(1-aziridinyl) phosphine oxide.
Uses	Tetrakis(hydroxymethyl)phosphonium chloride solution (80% in H₂O) has been used as a reducing agent and stabilizing ligand for the synthesis of gold nanoparticles (AuNPs) from gold(III) chloride trihydrate (HAuCl₄.3H₂O). It is a tetra-functional, amine-reactive, aqueous crosslinker that can be used for tuning the properties of protein-based hydrogels for 3D cell encapsulation applications.
Definition	A crystalline compound made by the reaction of phosphine, formaldehyde, and hydrochloric acid.
General Description	Clear slightly viscous,colorless to yellow liquid (20% H2O solution).
Air & Water Reactions	Hygroscopic. Water soluble.
Reactivity Profile	Tetrakis(hydroxymethyl)phosphonium chloride reacts vigorously with oxidizers and alkalis. Reacts with cellulose.
Health Hazard	ACUTE/CHRONIC HAZARDS: Tetrakis(hydroxymethyl)phosphonium chloride may be corrosive. When heated to decomposition, it may emit very toxic fumes of POx, hydrogen chloride and bis(chloromethyl)ether. Decomposition of Tetrakis(hydroxymethyl)phosphonium chloride in an aqueous environment may produce phosphine, formaldehyde and hydrogen chloride.
Fire Hazard	Tetrakis(hydroxymethyl)phosphonium chloride is probably combustible.
Flammability and Explosibility	Non flammable
Purification Methods	Crystallise it from AcOH and dry it at 100o in a vacuum. An 80% w/v aqueous solution has d4 1.33 [Reeves J Am Chem Soc 77 3923 1955]. [Beilstein 1 IV 3062.]