Products

Ethyl (R)-(-)-4-cyano-3-hydroxybutyate

Product Introduction

Ethyl (R)-(-)-4-cyano-3-hydroxybutyate Basic information

Product Name:	Ethyl (R)-(-)-4-cyano-3-hydroxybutyate
Synonyms:	(R)-(-)-4-CYANO-3-HYDROXYBUTYRIC ACID ETHYL ESTER;(R)-4-CYANO-3-HYDROXYBUTYRIC ACID ETHYL ESTER;(R)-(-)-ETHYL 4-CYANO-3-HYDROXYBUTYRATE;(R)-ETHYL 4-CYANO-3-HYDROXYBUTYRATE;(S)-4-CYANO-3-HYDROXYBUTANOATE ETHYL;ETHYL (3R)-4-CYANO-3-HYDROXY-BUTANOATE;ETHYL (S)-4-CYANO-3-HYDROXYBUTANOATE;ETHYL (R)-4-CYANO-3-HYDROXYBUTANOATE
CAS:	141942-85-0
MF:	C7H11NO3
MW:	157.17
EINECS:	430-220-6
Product Categories:	Atorvastatin intermediates;chiral;Alcohols, Hydroxy Esters and Derivatives;Chiral Compounds;INTERMEDIATESOFATORVASTATIN;API intermediates;Pharmaceutical Intermediates;141942-85-0
Mol File:	141942-85-0.mol

Ethyl (R)-(-)-4-cyano-3-hydroxybutyate Chemical Properties

alpha	-5 º (neat)
Boiling point	270 °C(lit.)
density	1.114 g/mL at 25 °C(lit.)
refractive index	n20/D 1.448(lit.)
Fp	>230 °F
storage temp.	2-8°C
solubility	Chloroform (Sparingly), DMSO (Slightly), Methanol (Slightly)
pka	13.03±0.20(Predicted)
form	Liquid
Specific Gravity	1.114
color	Colorless to yellow
optical activity	[α]25/D 5°, neat
BRN	5328715
InChIKey	LOQFROBMBSKWQY-ZCFIWIBFSA-N
CAS DataBase Reference	141942-85-0(CAS DataBase Reference)

Safety Information

MSDS Information

Provider	Language
SigmaAldrich	English
ALFA	English

Ethyl (R)-(-)-4-cyano-3-hydroxybutyate Usage And Synthesis

Chemical Properties	yellow liquid
Uses	analgesic, antipyretic, and anti-inflammatory
Uses	(3R)-4-Cyano-3-hydroxybutanoic Acid Ethyl Ester is used in a biocatalytic process for the synthesis of an atorvastatin intermediate and degredation products/impurities.
Application	Hydroxyglutaryl coenzyme A (HMG-CoA) reductase inhibitors are a new class of lipid-lowering drugs, and they have a market share of more than 10 billion US dollars in the current pharmaceutical field. They can selectively inhibit the rate-limiting enzyme HMG-CoA reductase in cholesterol synthesis in the liver, reduce liver lipoprotein production, and increase the expression of low-density lipoprotein (LDL) cholesterol receptors, thereby reducing plasma cholesterol levels. They can also significantly reduce very low-density lipoprotein (VLDL) and triglycerides, and increase anti-atherosclerotic high-density protein (HDL), preventing atherosclerosis and coronary heart disease. Ethyl (R)-(-)-4-cyano-3-hydroxybutyate is an important intermediate for the synthesis of HMG-CoA reductase inhibitors. If it is used as a raw material, synthetic atorvastatin is mainly used for the treatment of hypercholesterolemia and mixed hyperlipidemia, coronary heart disease and stroke.

Ethyl (R)-(-)-4-cyano-3-hydroxybutyate Preparation Products And Raw materials

Raw materials	Butanoic acid, 4-cyano-3-hydroxy-, (3R)--->Ethyl 4-bromo-3-hydroxybutyrate-->Sodium cyanide-->Ethanol-->Ethyl 4-chloroacetoacetate
Preparation Products	(3R,5R)-6-Cyano-3,5-dihydroxy-hexanoic Acid tert-Butyl Ester

Hot Tags: ethyl (r)-(-)-4-cyano-3-hydroxybutyate, China ethyl (r)-(-)-4-cyano-3-hydroxybutyate manufacturers, suppliers, factory, CAS 13048 33 4, Stearyl Methacrylate, Dipropylene Glycol Diacrylate, CAS 32360 05 7, 2 2 Ethoxyethoxy ethyl Acrylate, CAS 5888 33 5

Previous: No Information