Products

6-Hydroxy-1-tetralone

Product Introduction

6-Hydroxy-1-tetralone Basic information

Product Name:	6-Hydroxy-1-tetralone
Synonyms:	6-Hydroxy-3,4-dihydro-1(2H)-naphthalenone, 98%;6-HYDROXY-1-TETRALONE;6-HYDROXY-1-TETRALONE 98.5%;6-Hydroxy-3,4-dihydronaphthalen-1(2H)-one;6-hydroxyl-1-tetralone;4-dihydro-6-hydroxy-;1(2H)-Naphthalenone, 3,4-dihydro-6-hydroxy-;1-Tetralon-6-ol
CAS:	3470-50-6
MF:	C10H10O2
MW:	162.19
EINECS:
Product Categories:	Benzocycles;Alcohols and Derivatives;Carbonyl Compounds
Mol File:	3470-50-6.mol

6-Hydroxy-1-tetralone Chemical Properties

Melting point	154-157 °C(lit.)
Boiling point	358.0±31.0 °C(Predicted)
density	1.236±0.06 g/cm3(Predicted)
storage temp.	Inert atmosphere,Room Temperature
pka	8.22±0.20(Predicted)
form	Crystalline Powder
color	Off-white to brown
InChIKey	FNSQPQKPPGALFA-UHFFFAOYSA-N
CAS DataBase Reference	3470-50-6(CAS DataBase Reference)

Safety Information

MSDS Information

Provider	Language
SigmaAldrich	English

6-Hydroxy-1-tetralone Usage And Synthesis

Chemical Properties	gray powder
Uses	6-Hydroxy-1-tetralone is used as a starting material for a one-pot conversion of phenols to anilines.
Uses	6-Hydroxy-3,4-dihydro-1(2H)-naphthalenone (6-Hydroxy-1-tetralone) may be used in the synthesis of: 5-chloromethyl-6-hydroxy-3,4-dihydro-1(2H)-naphthalenone 6-(4-(3-(piperidin-1-yl)propoxy)benzyloxy)-1-tetralone 6-(3-(piperidin-1-yl)propoxy)-1-tetralone
Synthesis Reference(s)	Journal of Medicinal Chemistry, 41, p. 1068, 1998 DOI: 10.1021/jm970527v Journal of the American Chemical Society, 99, p. 5810, 1977 DOI: 10.1021/ja00459a052
General Description	6-Hydroxy-3,4-dihydro-1(2H)-naphthalenone (6-Hydroxy-1-tetralone) can be prepared by the demethylation of 6-methoxy-3,4-dihydro-1(2H)-naphthalenone. It participates in the synthesis of 2-alkylamino-6-hydroxy-5-hydroxymethyl-1,2,3,4-tetrahydro-1-naphthalenols. Its pKa value has been reported to be 7.74.

6-Hydroxy-1-tetralone Preparation Products And Raw materials

Raw materials	7-Hydroxy-1-tetralone
Preparation Products	6-CYANO-1-TETRALONE-->6-(benzyloxy)-3,4-dihydronaphthalen-1(2H)-one-->3-(((5-OXO-5,6,7,8-TETRAHYDRONAPHTHALEN-2-YL)OXY)METHYL)BENZONITRILE-->1-Naphthalenol, 2-bromo-1,2,3,4-tetrahydro-6-(phenylmethoxy)--->1(2H)-Naphthalenone, 6-[(4-bromophenyl)methoxy]-3,4-dihydro--->1(2H)-Naphthalenone, 3,4-dihydro-6-[(4-iodophenyl)methoxy]--->1(2H)-Naphthalenone, 6-[(4-fluorophenyl)methoxy]-3,4-dihydro-