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Aminoacetaldehyde Dimethyl Acetal

Product Introduction

Aminoacetaldehyde dimethyl acetal Basic information

Product Name:	Aminoacetaldehyde dimethyl acetal
Synonyms:	AMINOACETOLDEHYDE DIMETHYL ACETOL;2,2-Dimetoxyethyl Amine;2,2-Dimethoxyethylamin;Glycinal dimethyl acetal;Aminoacetaldehyd Dimethy Acetal;Aminoacetaldehyde dimethyl ace;anjiahuanchun;Aminoacetaldehyde dimethyl acetal ,98%
CAS:	22483-09-6
MF:	C4H11NO2
MW:	105.14
EINECS:	245-026-5
Product Categories:	Pharmaceutical Intermediates;1;22483-09-6
Mol File:	22483-09-6.mol

Aminoacetaldehyde dimethyl acetal Chemical Properties

Melting point	-78°C
Boiling point	135-139 °C/95 mmHg (lit.)
density	0.965 g/mL at 25 °C (lit.)
refractive index	n20/D 1.417(lit.)
Fp	128 °F
storage temp.	Keep in dark place,Inert atmosphere,2-8°C
solubility	soluble in Chloroform, Methanol
pka	6.95±0.10(Predicted)
form	Liquid
color	Clear colorless to pale yellow
Water Solubility	miscible
BRN	741868
InChIKey	QKWWDTYDYOFRJL-UHFFFAOYSA-N
CAS DataBase Reference	22483-09-6(CAS DataBase Reference)
NIST Chemistry Reference	Aminoacetaldehyde dimethyl acetal(22483-09-6)
EPA Substance Registry System	Ethanamine, 2,2-dimethoxy- (22483-09-6)

Safety Information

Hazard Codes	C,F,Xi
Risk Statements	10-34-36/37/38
Safety Statements	26-36/37/39-45-16-36
RIDADR	UN 1993 3/PG 3
WGK Germany	2
Hazard Note	Flammable/Corrosive
TSCA	Yes
HazardClass	3
PackingGroup	III
HS Code	29225000

MSDS Information

Provider	Language
2,2-Dimethoxyethylamine	English
ACROS	English
SigmaAldrich	English
ALFA	English

Aminoacetaldehyde dimethyl acetal Usage And Synthesis

Description	Aminoacetaldehyde dimethyl acetal, also known as 2,2-dimethoxy-ethylamine, is a critical intermediate in the synthesis of ivabradine hydrochloride, proline analogs, praziquantel, and other raw materials. The existing process for producing aminoacetal dimethyl acetate uses vinyl acetate as the starting material, and the target product is synthesized through bromination, Gabriel synthesis, and hydrazinolysis.
Chemical Properties	clear colorless to pale yellow liquid
Uses	Amino acetaldehyde dimethyl was used in preparation of chitosan- dendrimer hybrids having various functional groups such as carboxyl, ester and poly(ethylene glycol). It was used in an synthesis of a bicyclic proline analog from L-ascorbic acid and in 3-component reaction catalyzed by MgClO4 leading to α-aminophosphonates.
General Description	Aminoacetaldehyde dimethyl acetal reacts with sulfone, followed by hydrolysis and reductive amination by adding desired piperazine derivative to yield piperazine derivatives of 2-furanyl[1,2,4]triazolo[1,5-a][1,3,5]triazine.
Purification Methods	Dry the acetal over KOH pellets and distil it through a 30cm vacuum jacketed Vigreux column (p 11). [Lawson J Am Chem Soc 75 3398 1953, Erickson et al. J Am Chem Soc 77 6640 1955, Beilstein 4 IV 1918.]

Aminoacetaldehyde dimethyl acetal Preparation Products And Raw materials

Preparation Products

6-(bromomethyl)isoquinoline-->ethyl 2-(3-bromo-2-oxopyrazin-1(2H)-yl)acetate-->6-Bromoisoquinoline-->6-Methylisoquinoline-->ethyl 2-(3,4-dihydro-2,3-dioxopyrazin-1(2H)-yl)acetate-->8-METHYL-ISOQUINOLINE-->2-MERCAPTOIMIDAZOLE-->2-Aminoimidazole-->1-Methyl-1,3-dihydro-imidazol-2-one-->Glycine, N-(2,2-dimethoxyethyl)-, ethyl ester-->2-(4-BROMO-PHENYL)-1H-IMIDAZOLE-->7-Hydroxyisoquinoline-->3-Fluorobenzyl alcohol-->2,2-DIMETHOXY-N-(PHENYLMETHYLENE)-1-ETHANAMINE-->Methyl 3-(2,2-dimethoxyethylamino)propanoate-->N-[(3-Bromophenyl)methylene]-2,2-dimethoxyethanamine-->2-(3-FLUORO-PHENYL)-1H-IMIDAZOLE

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