4-Chlorobenzyl cyanide, 98+% 100GR;4-CHLOROBENZYL CYANIDE FOR SYNTHESIS;The effects of acetonitrile;(4-Chlorophenyl)acetonitrile 96%;(4-CHLOROPHENYL)ACETONITRILE;4-CHLOROBENZYL CYANIDE;CHLOROBENZYLCYANIDE-4;LABOTEST-BB LT00891700
CAS:
140-53-4
MF:
C8H6ClN
MW:
151.59
EINECS:
205-418-9
Product Categories:
Aromatic Nitriles
Mol File:
140-53-4.mol
4-Chlorobenzyl cyanide Chemical Properties
Melting point
25-28 °C(lit.)
Boiling point
265-267 °C(lit.)
density
1.19 g/mL at 20 °C(lit.)
refractive index
n20/D 1.543
Fp
>230 °F
storage temp.
Sealed in dry,Room Temperature
solubility
0.3g/l
form
Liquid After Melting
color
Clear colorless to yellow
BRN
971171
Exposure limits
NIOSH: IDLH 25 mg/m3
InChIKey
IVYMIRMKXZAHRV-UHFFFAOYSA-N
CAS DataBase Reference
140-53-4(CAS DataBase Reference)
NIST Chemistry Reference
Benzeneacetonitrile, 4-chloro-(140-53-4)
EPA Substance Registry System
Benzeneacetonitrile, 4-chloro- (140-53-4)
Safety Information
Hazard Codes
T,Xi
Risk Statements
23/24/25-36/37/38
Safety Statements
26-36/37/39-45-28B
RIDADR
UN 2811 6.1/PG 3
WGK Germany
3
RTECS
AL8250000
Hazard Note
Irritant/Toxic
TSCA
Yes
HazardClass
6.1
PackingGroup
II
HS Code
29269095
MSDS Information
Provider
Language
4-Chlorobenzyl cyanide
English
ACROS
English
SigmaAldrich
English
ALFA
English
4-Chlorobenzyl cyanide Usage And Synthesis
Chemical Properties
clear colorless to yellowish liquid after melting. Soluble in acetone and ethanol.
Uses
4-Chlorobenzyl cyanide is an intermediate for the preparation of 3-methyl-2-(4-chlorophenyl)butyric acid, which can be used to prepare pyrethroid insecticides such as fenvalerate and deltamethrin, and can be used in medicine Industrial preparation of pyrimethamine.
Preparation
4-Chlorobenzyl cyanide is obtained by the reaction of 4-Chlorobenzyl chloride with sodium cyanide. Add 4-Chlorobenzyl chloride and Benzyldodecyldimethylammonium bromide into the reaction pot, heat to 100°C, slowly add sodium cyanide aqueous solution, and react at 100-104°C for 5h (add sodium cyanide for 3h, keep warm for 2h). Then add water to dissolve sodium chloride, and separate the water layer to obtain the crude benzyl chloride cyanide, which is distilled under reduced pressure to collect 160 (2.66kPa) fractions to obtain the finished product of 4-Chlorobenzyl cyanide. The yield is above 81%.
Definition
ChEBI: 4-Chlorobenzyl cyanide is a nitrile that is acetonitrile in which one of the hydrogens has been replaced by a p-chlorophenyl group. It is a member of monochlorobenzenes and a nitrile. It derives from an acetonitrile.
4-Chlorobenzyl cyanide Preparation Products And Raw materials
