Product Introduction
| Aminoacetonitrile hydrochloride Basic information |
| Product Name: | Aminoacetonitrile hydrochloride |
| Synonyms: | aminoacetonitrilemonohydrochloride;amino-acetonitrilmonohydrochloride;glycinonitrile,monohydrochloride;2-AminoacetonitrileHydrochloride;GlycinonitrileHCl;Aminoacetonitrilehydrochloride,97%;Acetonitrile, amino-, monohydrochloride;AMINOACETONITRILE A.K.A. GLYCINONITRILE HYDROCHLOR |
| CAS: | 6011-14-9 |
| MF: | C2H5ClN2 |
| MW: | 92.53 |
| EINECS: | 227-865-9 |
| Product Categories: | Pharmaceutical Intermediates;straight chain compounds |
| Mol File: | 6011-14-9.mol |
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| Aminoacetonitrile hydrochloride Chemical Properties |
| Melting point | 172-174°C |
| RTECS | MC1950000 |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Methanol (Slightly, Heated), Water |
| form | Powder |
| color | White to Off-White |
| Water Solubility | Soluble in water 20°C, 1000g/L. |
| Sensitive | Hygroscopic |
| Merck | 14,412 |
| CAS DataBase Reference | 6011-14-9(CAS DataBase Reference) |
| EPA Substance Registry System | Aminoacetonitrile hydrochloride (6011-14-9) |
| Safety Information |
| Risk Statements | 20/21/22-36/37/38-25 |
| Safety Statements | 22-36/37-45-26 |
| RIDADR | 3439 |
| TSCA | Yes |
| HazardClass | 6.1 |
| PackingGroup | III |
| HS Code | 29269090 |
| MSDS Information |
| Provider | Language |
|---|---|
| Aminoacetonitrile hydrochloride | English |
| ALFA | English |
| Aminoacetonitrile hydrochloride Usage And Synthesis |
| Chemical Properties | White to light brown solid |
| Uses | Used as pharmaceutical intermediates, organic synthetic raw material transportation. |
| Application | Aminoacetonitrile is a useful synthetic intermediate. It is a reagent used to synthesize dipeptide nitriles as reversible and potent cathepsin S inhibitors. It can also used to prepare substituted cyclic ureas as possible HIV protease inhibitors. |
| Preparation | Synthesis of Aminoacetonitrile Hydrochloride by Reaction of Aminoacetonitrile with Hydrogen Chloride in Methanol: mixing the aminoacetonitrile with hydrogen chloride methanol solution, reacting at 45-50°C for 1-2 hours, cooling to below 5°C, filtering, and centrifugalizing to obtain the aminoacetonitrile hydrochloride, wherein in the hydrogen chloride methanol solution, the content of hydrogen chloride is 30-50 wt%, and the water content is less than or equal to 1%. Preparation method of aminoacetonitrile hydrochloride |
| Safety Profile | An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx and HCl. |
| Purification Methods | The salt recrystallises from dilute EtOH as hygroscopic leaflets. It is best to crystallise it from absolute EtOH/Et2O (1:1) and then recrystallise it from absolute EtOH. The melting point recorded ranges from 144o to 174o. The free base has b 58o/15mm with partial decomposition. [Klages J Prakt Chem [2] 65 189 1902, Mange J Am Chem Soc 56 2197 1934, Goldberg & Kelly J Chem Soc 1371 1947, Beilstein 4 H 344, 4 I 468, 4 II 783, 4 III 1120, 4 IV 2363.] |
| Aminoacetonitrile hydrochloride Preparation Products And Raw materials |
| Preparation Products | 1-AMINOCYCLOPROPANECARBONITRILE-->2-AMINOPENT-4-YNENITRILE-->Momelotinib-->3-Indoleacetonitrile-->(4-FLUOROPHENYLTHIO)ACETONITRILE-->N-(tert-Butoxycarbonyl)-2-aminoacetonitrile-->4-Biphenylacetonitrile-->2-Methylbenzyl cyanide-->Acetonitrile, 2-isothiocyanato--->N-(CYANOMETHYL)-4-METHYLBENZAMIDE-->N-(CYANOMETHYL)ACETAMIDE-->3,4-Dichlorophenylacetonitrile |
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