Clopidol

Clopidol

Product Introduction

Clopidol Basic information
Product Name: Clopidol
Synonyms: 3,5-dichloro-2,6-dimethyl-4-pyridino;ClopidolMeticlopidol;coccidiostatc;4-Pyridinol, 3,5-dichloro-2,6-dimethyl-;3,5-DICHLORO-2 98+%;Clopidol -Total dust;Clopidol, respirable dust;Clopindol
CAS: 2971-90-6
MF: C7H7Cl2NO
MW: 192.04
EINECS: 221-008-2
Product Categories: Aromatics;Intermediates & Fine Chemicals;Food and Feed Additive;Active Pharmaceutical Ingredients;Veterinaries;Pharmaceuticals;Organics;2971-90-6
Mol File: 2971-90-6.mol
Clopidol Structure
 
Clopidol Chemical Properties
Melting point >320℃
Boiling point 318.4±37.0 °C(Predicted)
density 1.2494 (rough estimate)
refractive index 1.5500 (estimate)
storage temp. Inert atmosphere,Room Temperature
solubility Aqueous Base (Slightly), Methanol (Slightly, Heated)
pka 5.50±0.33(Predicted)
color White to Off-White
Water Solubility 40mg/L(temperature not stated)
Stability: Hygroscopic
InChIKey QCMHHYSPKNVXLR-UHFFFAOYSA-N
CAS DataBase Reference 2971-90-6(CAS DataBase Reference)
EPA Substance Registry System Clopidol (2971-90-6)
 
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26
OEB B
OEL TWA: 10 mg/m3 (total), STEL: 20 mg/m3 (total)
WGK Germany 2
RTECS UU7711500
HS Code 29333990
Hazardous Substances Data 2971-90-6(Hazardous Substances Data)
Toxicity LD50 orally in rats: 18 g/kg (Plisek)
 
MSDS Information
 
 
Clopidol Usage And Synthesis
Description The drug methylchlorpindol is used for the prevention of coccidiosis in poultry.
Description Clopidol is a coccidiostat. It prevents mortality of chickens infected with the parasites E. tenella, E. necatrix, E. acervuline, E. mivati, E. brunetti, and E. maxima. It has antimalarial activity against P. berghei in mice and P. cynomologi in rhesus macaques. Clopidol is a potential contaminant in food poultry. Formulations containing clopidol have been used in the prevention of coccidiosis in chickens.
Chemical Properties Clopidol is a white to light brown powder.
Clopidol
Uses GABA Cl channel agonist, antiparasitic
Uses An antibiotic used in veterinary medicine as a coccidiostat in poultry. Showed low order of acute and chronic toxicity in animals.
Uses An antiprotozoal agent.
Definition A penta-substituted pyridine derivative.
General Description White to light-brown, crystalline solid. Mp: 320°C. Practically insoluble in water. Administered to poultry to prevent the growth of pathogenic parasites.
Reactivity Profile Clopidol is a non-combustible as a solid, but dust may burn rapidly or explode when mixed with air and ignited.
Hazard Toxic. Mutagenic effects. Questionable carcinogen. Clopyralid.
Contact allergens This drug is used for the prevention of coccidiosis in poultry.
Safety Profile A nuisance dust. When heated to decomposition it emits very toxic fumes of Cland NOx.
Potential Exposure Those engaged in formulation, application or manufacture of this veterinary antibiotic. Used as a pharmaceutical and as feed and food additive
First aid If this chemical gets into the eyes, remove anycontact lenses at once and irrigate immediately for at least15 min, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts theskin, remove contaminated clothing and wash immediatelywith soap and water. Seek medical attention immediately. Ifthis chemical has been inhaled, remove from exposure,begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR ifheart action has stopped. Transfer promptly to a medicalfacility. When this chemical has been swallowed, get medical attention. Give large quantities of water and inducevomiting. Do not make an unconscious person vomit.
storage Color Code-Blue: Health Hazard/Poison: Storein a secure poison location. Prior to working with clopidolyou should be trained on its proper handling and storage.Store in tightly closed containers in a cool, well-ventilatedarea.
Shipping UN3249 Medicine, solid, toxic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials.
Incompatibilities Noncombustible solid, but dust may explode in cloud form. Contact with strong oxidizers may cause a fire or explosion hazard
Waste Disposal Dispose of contents and container to an approved waste disposal plant. All federal, state, and local environmental regulations must be observed. It is inappropriate and possibly dangerous to the environment to dispose of expired or waste drugs and pharmaceuticals by flushing them down the toilet or discarding them to the trash. Household quantities of expired or waste pharmaceuticals may be mixed with wet cat litter or coffee grounds, double-bagged in plastic, discard in trash. Larger quantities shall carefully take into consideration applicable DEA, EPA, and FDA regulations. If possible return the pharmaceutical to the manufacturer for proper disposal being careful to properly label and securely package the material. Alternatively, the waste pharmaceutical shall be labeled, securely packaged, and transported by a state licensed medical waste contractor to dispose by burial in a licensed hazardous or toxic waste landfill or incinerator.
 
Clopidol Preparation Products And Raw materials
Raw materials Dehydroacetic acid-->4-Hydroxy-2,6-dimethylpyridine

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