Products

Home / Products/ Organic Chemistry / Ketones

2-Hydroxy-2-methylpropiophenone

Send Inquiry

Product Introduction

2-Hydroxy-2-methylpropiophenone Basic information

Uses

Product Name:	2-Hydroxy-2-methylpropiophenone
Synonyms:	Photocure-1173;1-Phenyl-2-Hydroxy-2-Methyl-1-Propanone;2-Hydroxy-2-Methylpheny-Propane-1-one;1-Propanone, 2-hydroxy-2-methyl-1-phenyl-;ACETOCURE 73;1-Phenyl-2-hydroxy-2-methylpropane-1-one;1-Phenyl-2-methyl-2-hydroxy-1-propanone;2-Hydroxy-2-methyl-1-phenylpropane-1-one
CAS:	7473-98-5
MF:	C10H12O2
MW:	164.2
EINECS:	231-272-0
Product Categories:	Other Products;Functional Materials;Photopolymerization Initiators;Acetophenone;Organic Photoinitiators;Polymerization Initiators;Industrial/Fine Chemicals;Additives for Plastic;Pharmaceutical Intermediates
Mol File:	7473-98-5.mol

2-Hydroxy-2-methylpropiophenone Chemical Properties

Melting point	4°C
Boiling point	102-103 °C4 mm Hg(lit.)
density	1.077 g/mL at 25 °C(lit.)
vapor pressure	0.57Pa at 20℃
refractive index	n20/D 1.533(lit.)
Fp	>230 °F
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	Practically insoluble in water
form	clear liquid
pka	13.23±0.29(Predicted)
Specific Gravity	1.077
color	Colorless to Light orange to Yellow
Water Solubility	13.3g/L at 20℃
InChIKey	XMLYCEVDHLAQEL-UHFFFAOYSA-N
LogP	1.62 at 25℃
CAS DataBase Reference	7473-98-5(CAS DataBase Reference)
EPA Substance Registry System	1-Propanone, 2-hydroxy-2-methyl-1-phenyl- (7473-98-5)

Safety Information

Hazard Codes	Xn
Risk Statements	22
Safety Statements	23-36/37/39
RIDADR	3082
WGK Germany	3
RTECS	UC2977245
HazardClass	9
PackingGroup	III
HS Code	29144000

MSDS Information

Provider	Language
SigmaAldrich	English

2-Hydroxy-2-methylpropiophenone Usage And Synthesis

Uses	2-Hydroxy-2-methylpropiophenone is a photoinitiator.In addition, 2-hydroxy-2-methylpropiophenone is an important organic intermediate (building block) to synthetize substituted propiophenone products.
Chemical Properties	Yellowish clear liquid
Uses	2-Hydroxy-2-benzoylpropane was used as a catalyst in real-time kinetic study of laser-induced polymerization. It is also a photoinitiator.
Synthesis Reference(s)	Tetrahedron Letters, 29, p. 4365, 1988 DOI: 10.1016/S0040-4039(00)80496-7
General Description	2-Hydroxy-2-methylpropiophenone is a radical photoinitiator (PI) molecule that can be used in the crosslinking of polymers by the exposure of UV radiation. It can be used in the development of UV curable resins for exterior coating applications.
Hazard	Moderately toxic by ingestion.
Flammability and Explosibility	Not classified
Synthesis	KBr in water is added to a solution of 2-methyl-1-phenylpropane-1,2-diol in toluene. Then, TEMPO is added. The reddish suspension is cooled to 0°C. A 12 % sodium hypochlorite solution is added while maintaining the internal temperature at 5°C or lower. The mixture is stirred for 1 h at 0-5°C and then separated for 10 min. Sodium dithionite solution (obtained from 30 g sodium dithionite (85%) and 400 ml of water)is added to the organic phase and stirred at 85°C for 1-2 h. The organic phase is again separated and concentrated (rotavap). The crude product is then subjected to fractional distillation, yielding 2-Hydroxy-2-methylpropiophenone as a colorless oil.