Products

4-Amino-3-chlorophenol

Product Introduction

4-Amino-3-chlorophenol Basic information

Product Name:	4-Amino-3-chlorophenol
Synonyms:	AMINO(4-)-3-CHLOROPHENOL;4-AMINO-3-CHLOROPHENOL;3-chloro-4-aminophenol;4-amino-3-chloro-pheno;Brn 2802558;Einecs 241-583-3;Phenol, 4-amino-3-chloro-;lenvaint-G
CAS:	17609-80-2
MF:	C6H6ClNO
MW:	143.57
EINECS:	241-583-3
Product Categories:	17609-80-2
Mol File:	17609-80-2.mol

4-Amino-3-chlorophenol Chemical Properties

Melting point	159-160℃
Boiling point	287.3±25.0 °C(Predicted)
density	1.406±0.06 g/cm3(Predicted)
RTECS	SJ5710000
storage temp.	2-8°C(protect from light)
solubility	DMSO (Slightly), Methanol (Slightly)
pka	9.26±0.18(Predicted)
form	Crystalline Powder
color	White
Stability:	Hygroscopic
CAS DataBase Reference	17609-80-2(CAS DataBase Reference)

Safety Information

HazardClass	6.1
HS Code	2922290090

MSDS Information

4-Amino-3-chlorophenol Usage And Synthesis

Chemical Properties	Light yellow solid
Uses	4-Amino-3-Chlorophenol acts as a synthetic reagent for the preparation of Benzothiazole-based ureas as potential ABAD/17β-HSD10 modulators for Alzheimer''s disease treatment.
Application	The 4-amino-3-chlorophenol is a crucial intermediate for preparing a tyrosine kinase inhibitor, tivozanib, and a late liver cancer drug, lenvatinib. As a crucial pharmaceutical chemical intermediate, 4-amino-3-chlorophenol is widely applied to the design and synthesis of medicaments for resisting tumors, cardiovascular diseases, neurological diseases, and the like.
Synthesis	Starting from o-chloronitrobenzene with introducing hydroxyl groups in the presence of strong acids and molybdenum salts as catalysts could synthesize 4-amino-3-chlorophenol. Besides, using m-chlorophenol as a starting material and introducing hydroxyl on a benzene ring through diazotization and coupling also could synthesize 4-Amino-3-chlorophenol.