pyridine,3,5-dimethyl-;Lutidine,98%;3 5-LUTIDINE STANDARD FOR GC;3,5-LUTIDINE, 98+%;3,5-DIMETHYLPYRIDINE 98+%;3,5-Dimetylpyridine;3,5-Lutidine,99%;3,5-dimethyl-pyridin
CAS:
591-22-0
MF:
C7H9N
MW:
107.15
EINECS:
209-708-6
Product Categories:
Biochemistry;Reagents for Oligosaccharide Synthesis;Pyridines derivates;Heterocyclic Compounds;K00001
Mol File:
591-22-0.mol
3,5-Lutidine Chemical Properties
Melting point
-9 °C (lit.)
Boiling point
169-170 °C (lit.)
density
0.939 g/mL at 25 °C (lit.)
vapor pressure
1.5 mm Hg ( 20 °C)
refractive index
n20/D 1.504(lit.)
Fp
128 °F
storage temp.
2-8°C
pka
6.15(at 25℃)
form
Liquid
color
Clear yellow
Water Solubility
33 g/L (20 ºC)
Sensitive
Hygroscopic
BRN
105682
InChIKey
HWWYDZCSSYKIAD-UHFFFAOYSA-N
LogP
1.780
CAS DataBase Reference
591-22-0(CAS DataBase Reference)
NIST Chemistry Reference
Pyridine, 3,5-dimethyl-(591-22-0)
EPA Substance Registry System
3,5-Dimethylpyridine (591-22-0)
Safety Information
Hazard Codes
Xn,F,Xi,T
Risk Statements
10-20/21/22-36/37/38-41-34-23/25-21
Safety Statements
16-26-36-36/37-45-36/37/39
RIDADR
UN 1993 3/PG 3
WGK Germany
3
F
8
Hazard Note
Irritant/Flammable
TSCA
Yes
HazardClass
3
PackingGroup
III
HS Code
29333999
MSDS Information
Provider
Language
3,5-Dimethylpyridine
English
SigmaAldrich
English
ACROS
English
ALFA
English
3,5-Lutidine Usage And Synthesis
Chemical Properties
CLEAR YELLOW LIQUID
Uses
3,5-Lutidine is a reactant used in the synthesis of phthalazine and pyrazine compounds, as well as other pharmaceuticals.
Synthesis Reference(s)
Synthesis, p. 573, 1994 DOI: 10.1055/s-1994-25526
Flammability and Explosibility
Flammable
Purification Methods
Dry 3,5-lutidine with sodium and fractionally distil it through a Todd column (p 11) packed with glass helices. Dissolve (100mL) in dilute HCl (1:4) and steam distil this until 1L of distillate is collected. Excess conc NaOH is added to the residue which is again steam distilled. The base is extracted from the distillate, using diethyl ether. The extract is dried over K2CO3, and distilled. It is then fractionally crystallised by partial freezing. The hydrochloride has m 229o(sublimes at 190-231o), and the picrate has m 242-243o(dec, from H2O), 249-250o(dec, from AcOH). [Beilstein 20 II 161, 20 III/IV 2788, 20/6 V 60.]
3,5-Lutidine Preparation Products And Raw materials
