Aldehydes;Building Blocks;C8;Carbonyl Compounds;Chemical Synthesis;Organic Building Blocks;Aromatic Aldehydes & Derivatives (substituted);aldehyde;Pyridines;bc0001
Mol File:
591-31-1.mol
3-Methoxybenzaldehyde Chemical Properties
Melting point
187 °C
Boiling point
143 °C50 mm Hg(lit.)
density
1.117 g/mL at 20 °C(lit.)
vapor pressure
1.3 hPa (73 °C)
refractive index
n20/D 1.553(lit.)
Fp
>230 °F
storage temp.
Store below +30°C.
solubility
Chloroform, Methanol (Slightly)
form
Liquid
color
Clear pale yellow to yellow
Specific Gravity
1.118
Odor
at 100.00?%. anisic
Water Solubility
insoluble
Sensitive
Air Sensitive
BRN
606013
LogP
1.710
CAS DataBase Reference
591-31-1(CAS DataBase Reference)
NIST Chemistry Reference
Benzaldehyde, 3-methoxy-(591-31-1)
EPA Substance Registry System
Benzaldehyde, 3-methoxy- (591-31-1)
Safety Information
Hazard Codes
Xi
Risk Statements
36/37/38-36/38
Safety Statements
26-36-37/39
WGK Germany
3
RTECS
BZ2605000
F
9-23
Autoignition Temperature
225 °C
TSCA
Yes
HazardClass
IRRITANT
HS Code
29124900
Toxicity
sce-hmn:lyms 1 mmol/L MUREAV 206,17,88
MSDS Information
Provider
Language
m-Anisaldehyde
English
ACROS
English
SigmaAldrich
English
ALFA
English
3-Methoxybenzaldehyde Usage And Synthesis
Chemical Properties
clear pale yellow to yellow liquid
Uses
3-Methoxybenzaldehyde is used to prepare 3-(3-methoxy-phenyl)-1-phenyl-propenone by reaction with benzldehyde. It is used as an eluent for mono-13C isotopomers of vanillin in normal phase silica gel chromatography. It acts as an inhibitor of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) metabolism.
Definition
ChEBI: 3-methoxybenzaldehyde is a member of the class of benzaldehydes in which the hydrogen at position 3 of benzaldehyde has been replaced by a methoxy group. It has a role as a Brassica napus metabolite. It is a member of benzaldehydes and a monomethoxybenzene.
Synthesis Reference(s)
Synthetic Communications, 24, p. 2011, 1994 DOI: 10.1080/00397919408010209
General Description
m-Anisaldehyde has significant antifungal activity against Candida sp., including the azole-resistant strains.
Safety Profile
Mutation data reported. Whenheated to decomposition it emits acrid smoke andirritating vapors.
Purification Methods
Wash it with saturated aqueous NaHCO3, then H2O, dry it with anhydrous MgSO4 and distil it under reduced pressure under N2. Store it under N2 in sealed glass ampoules. [Beilstein 8 IV 241.]
3-Methoxybenzaldehyde Preparation Products And Raw materials
