Products

1-Tetralone

Product Introduction

1-Tetralone Basic information

Product Name:	1-Tetralone
Synonyms:	KETOTETRAHYDRONAPHTHALENE;A-TETRALONE;1,2,3,4-TETRAHYDRO-1-NAPHTHALENONE;1-TETRALONE;3,4-DIHYDRO-2H-NAPHTHALEN-1-ONE;3,4-DIHYDRO-1-(2H)NAPHTHALENEONE;3,4-DIHYDRO-1(2H)-NAPHTHALENONE;ALPHA-TETRALONE
CAS:	529-34-0
MF:	C10H10O
MW:	146.19
EINECS:	208-460-6
Product Categories:	Bioactive Small Molecules;Building Blocks;C10;Carbonyl Compounds;Cell Biology;Chemical Synthesis;PHARMACEUTICAL INTERMEDIATES;Ketones;Organic Building Blocks;T;Cardiovascular & Blood System Agents;pharmaceutical;bc0001;529-34-0
Mol File:	529-34-0.mol

1-Tetralone Chemical Properties

Melting point	2-7 °C(lit.)
Boiling point	113-116 °C6 mm Hg(lit.)
density	1.099 g/mL at 25 °C(lit.)
refractive index	n20/D 1.568(lit.)
Fp	>230 °F
storage temp.	2-8°C
solubility	Chloroform, Ethyl Acetate (Slightly)
form	Liquid
color	brown
Water Solubility	insoluble
BRN	607374
InChIKey	XHLHPRDBBAGVEG-UHFFFAOYSA-N
CAS DataBase Reference	529-34-0(CAS DataBase Reference)
NIST Chemistry Reference	1(2H)-Naphthalenone, 3,4-dihydro-(529-34-0)
EPA Substance Registry System	1,2,3,4-Tetrahydronaphthalen-1-one (529-34-0)

Safety Information

Hazard Codes	Xn
Risk Statements	22-20/22-20/21/22
Safety Statements	23-24/25-36
WGK Germany	3
RTECS	QK4375000
TSCA	Yes
HS Code	29143900
Hazardous Substances Data	529-34-0(Hazardous Substances Data)
Toxicity	LD50 orally in Rabbit: 810 mg/kg LD50 dermal Rabbit > 2200 mg/kg

MSDS Information

1-Tetralone Usage And Synthesis

Chemical Properties	Clear amber to brown oily liquid
Uses	1-Tetralone is a reagent used in the synthesis of amino-pyrazolopyridines with anti-NF-κB and pro-apoptotic potential.
Synthesis Reference(s)	Tetrahedron Letters, 32, p. 4291, 1991 DOI: 10.1016/S0040-4039(00)92151-8
Purification Methods	Check the IR first. Purify α-tetralone by dissolving 20mL in Et2O (200mL), washing with H2O (100mL), 5% aqueous NaOH (100mL), H2O (100mL), 3% aqueous AcOH (100mL), 5% NaHCO3 (100mL) then H2O (100mL) and dry the ethereal layer over MgSO4. Filter, evaporate and fractionate the residue through a 6in Vigreux column (p 11) under reduced pressure to give a colourless oil (~17g) with b 90-91o/0.50.7mm. [Snyder & Werber Org Synth Coll Vol III 798 1955.] It has also been fractionated through a 0.5metre packed column with a heated jacket under reflux using a partial take-off head. It has max 247.5 and 290nm (hexane). The phenylhydrazone has m 83o. The 2,4,6-trinitrophenylhydrazone has m 247.5-248o (from EtOH). [Olson & Bader Org Synth Coll Vol IV 898 1963, Beilstein 7 H 370, 7 III 1416, 7 IV 1015.]

1-Tetralone Preparation Products And Raw materials

Raw materials	Aluminum chloride-->Hydrogen fluoride-->Polyphosphoric acid-->Phosphorus pentoxide-->Tin tetrachloride-->Butyryl chloride-->Gamma Butyrolactone-->4-Phenylbutyric acid-->1,2,3,4-Tetrahydronaphthalene-->5-Ethyl-2-methylpyridine-->Chromic acetate-->1(2H)-Naphthalenone, 3,4-dihydro-, 2,2-dimethylhydrazone-->(4,4-Difluoro-3-buten-1-yl)benzene-->4-Phenylbutyryl chloride
Preparation Products	(S)-(-)-1,2,3,4-Tetrahedro-naphthoic acid-->γ-Hydroxybutyrophenone-->7-Hydroxy-1-tetralone-->2,3-Dihydro-1,4-naphthoquinone-->(S)-(+)-1,2,3,4-Tetrahydro-1-naphthol