pharmacetical;Organic acids;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds;Halogenated Heterocycles ,Pyrimidines;119-80-2
Mol File:
119-80-2.mol
2,2'-Dithiosalicylic acid Chemical Properties
Melting point
287-290 °C(lit.)
Boiling point
416.97°C (rough estimate)
density
1.4555 (rough estimate)
vapor pressure
0Pa at 25℃
refractive index
1.4950 (estimate)
storage temp.
Refrigerator
solubility
DMSO (Slightly), Methanol (Slightly)
form
Powder
pka
3.02±0.36(Predicted)
color
Brown
Water Solubility
insoluble
BRN
2221810
InChIKey
LBEMXJWGHIEXRA-UHFFFAOYSA-N
LogP
1.61 at 25℃ and pH6.2-6.48
CAS DataBase Reference
119-80-2(CAS DataBase Reference)
EPA Substance Registry System
Benzoic acid, 2,2'-dithiobis- (119-80-2)
Safety Information
Hazard Codes
Xi
Risk Statements
36/37/38
Safety Statements
26-36-24/25
WGK Germany
3
RTECS
DG9660000
Hazard Note
Harmful/irritant
TSCA
Yes
HS Code
29309070
Toxicity
LD50 ipr-mus: 367 mg/kg ARZNAD 21,284,71
MSDS Information
Provider
Language
2,2'-Dithiodibenzoic acid
English
SigmaAldrich
English
ACROS
English
ALFA
English
2,2'-Dithiosalicylic acid Usage And Synthesis
Chemical Properties
brown powder
Uses
2,2'-Dithiosalicylic acid is an organosulfur compound produced from dibenzothiophene metabolites that is in turn biodegraded into transient metabolites such as benzoic acid.It is used in the preparation of a new class of anti-HIV-1 agents.
Uses
2,2′-Dithiodibenzoic acid may be used for the preparation of novel anionic heptadecanuclear silver(I) cluster, by the reaction with equivalent molar silver oxide under ultrasonic conditions at 50°C. It may be used for the preparation of polyamides containing a disulfide bond in their main chain.
General Description
2,2′-Dithiodibenzoic acid is an sulfhydryl modifying reagent. 2,2′-Dithiodibenzoic acid on cocrystallization with imidazole or 4-methylimidazole affords bis(imidazolium) 2,2′-dithiodibenzoate and 4-methylimidazolium 2-[(2-carboxyphenyl)disulfanyl]benzoate organic salt, respectively. It also cocrystallizes with isonicotinohydrazide from methanol solution to afford the 1:2 cocrystal, 2,2′-dithiodibenzoic acid-isonicotinohydrazide.
Safety Profile
Poison by intraperitoneal route.When heated to decomposition it emits toxic vapors ofSOx.
Synthesis
A preparation method of 2,2'-dithiosalicylic acid is as follows: using anthranilic acid as raw material and performing a diazotization reaction with sodium nitrite and hydrochloric acid at 0 to 10°C to obtain a diazo liquid. The liquid reacts with liquid sulfur dioxide for 0.5 to 3 hours in the presence of a catalyst and a cocatalyst at -20~~-10°C and then is kept at 80~100°C for 0.5~2 hours, cooled, and filtered to obtain 2,2'-Dithiosalicylic acid.
2,2'-Dithiosalicylic acid Preparation Products And Raw materials
