Sodium trifluoromethanesulfinate Chemical Properties
Melting point
<325°C
storage temp.
Keep in dark place,Inert atmosphere,Room temperature
solubility
Water (Sparingly)
form
powder
color
white
BRN
3723394
InChIKey
KAVUKAXLXGRUCD-UHFFFAOYSA-M
Safety Information
Hazard Codes
Xi
Risk Statements
36/37/38-36/38
Safety Statements
26-36/37/39
WGK Germany
3
TSCA
No
HazardClass
IRRITANT
HS Code
29309090
MSDS Information
Sodium trifluoromethanesulfinate Usage And Synthesis
Chemical Properties
White to light yellow solid
Uses
Efficient sulfinate salt for the trifluoromethylation of various aryls, aryl boronic acids, alkenes, and alkynes.
Uses
Sodium Triflinate (Sodium trifluoromethanesulfinate), is a sulfur-containing building block and Fluorination reagents, used in various organic synthesis. It can be used in a new and convenient method for the copper-catalyzed construction of functional sulfonamides in good yields and excellent chemoselectivity.
Solubility in water
soluble in H2O, slightly soluble in MeOH, MeCN, and acetone.
Synthesis
At first, an aqueous solution was prepared by dissolving 37.5 g of sodium sulfite in 150 g of water. Then, a metal pressure-proof reactor was charged with this aqueous solution. After that, the atmosphere of the reactor was removed to obtain a reduced pressure. 10.7 g of trifluoromethanesulfonic fluoride was added to the reactor, stirring at 5° C. for 4 hr. The resulting reaction liquid was neutralized with sodium carbonate, followed by water removal. Then, methanol was added to the remaining solid matter to extract the target product. The resulting methanol solution was concentrated to dryness, thereby obtaining 9.7 g of sodium trifluoromethanesulfinate (yield: 88%).
Sodium trifluoromethanesulfinate Preparation Products And Raw materials
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