Products

2,4'-Dibromoacetophenone

Product Introduction

2,4'-Dibromoacetophenone Basic information

Product Name:	2,4'-Dibromoacetophenone
Synonyms:	P-BROMOPHENACYL BROMIDE;PBPB;OMEGA-BROMOACETOPHENONE;bromomethyl4-bromophenylketone;bromomethylp-bromophenylketone;omega,4-dibromoacetophenone;p,alpha-dibromoacetophenone;p-bromophenacyl-8
CAS:	99-73-0
MF:	C8H6Br2O
MW:	277.94
EINECS:	202-783-6
Product Categories:	Other enzyme inhibitors and activators;Aromatic Acetophenones & Derivatives (substituted);Carboxyl Group Labeling Reagents for HPLC;UV Detection (HPLC Labeling Reagents);Analytical Chemistry;HPLC Labeling Reagents;Adehydes, Acetals & Ketones;Bromine Compounds;Analytical Reagents;Analytical/Chromatography;Bioactive Small Molecules;Biochemicals and Reagents;Building Blocks;C7 to C8;Carbonyl Compounds;Cell Biology;Chemical Synthesis;D-DIF;Derivatization agents;Derivatization Reagents;Derivatization Reagents HPLC;Fluorescence;Halogenated;Ketones;Luminescent Compounds/Detection;Organic Building Blocks
Mol File:	99-73-0.mol

2,4'-Dibromoacetophenone Chemical Properties

Melting point	108-110 °C(lit.)
Boiling point	1415°C/760mm
density	1.7855 (rough estimate)
refractive index	1.5560 (estimate)
storage temp.	Store below +30°C.
solubility	DMF: 5 mg/ml; DMSO: 2 mg/ml; Ethanol: 1 mg/ml; PBS (pH 7.2): insol
form	Crystalline Solid
color	Slightly yellow to beige
Water Solubility	Soluble in dimethyl sulfoxide (5 mg/ml), methanol (20 mg/ml), toluene and ethanol. Insoluble in water.
Sensitive	Lachrymatory
Merck	14,1427
BRN	607604
Stability:	Stable. Incompatible with strong bases, strong reducing agents, strong oxidizing agents.
InChIKey	FKJSFKCZZIXQIP-UHFFFAOYSA-N
CAS DataBase Reference	99-73-0(CAS DataBase Reference)
EPA Substance Registry System	Ethanone, 2-bromo-1-(4-bromophenyl)- (99-73-0)

Safety Information

Hazard Codes	C
Risk Statements	34
Safety Statements	26-36/37/39-45
RIDADR	UN 3261 8/PG 2
WGK Germany	2
RTECS	AM6950000
F	19-21
Hazard Note	Corrosive/Lachrymatory
TSCA	T
HazardClass	8
PackingGroup	III
HS Code	29147090

MSDS Information

Provider	Language
2,4'-Dibromoacetophenone	English
SigmaAldrich	English
ACROS	English
ALFA	English

2,4'-Dibromoacetophenone Usage And Synthesis

Chemical Properties	2,4'-Dibromoacetophenone is off-white crystals or powder
Uses	Undergoes condensation reactions with aldehydes in the presence of SnCl21 or SmI32 to afford α,β-unsaturated ketones. Also useful in the esterification of carboxylic acids.3
Uses	Identification of carboxylic acids.
Uses	2,4'-Dibromoacetophenone is used as a reagent for analysis of fatty acids by HPLC as 4-bromophenacyl esters, for use in the protection of phenols and carboxylic acids. It undergoes condensation reactions with aldehydes in the presence of SnCl2 or SmI3 to afford α,β-unsaturated ketones. It is also useful in the esterification of carboxylic acids.
General Description	A phenyl α-bromomethyl ketone compound that acts as a cell-permeable, and non-ATP competitive inhibitor of GSK-3β (IC₅₀ = 0.5 μM). This reactive alkylating agent is selective towards GSK-3β and does not affect PKA activity even at concentrations as high as 100 μM.
Biochem/physiol Actions	Cell permeable: yes
Purification Methods	Crystallise the bromide from EtOH (ca 8mL/g). [Beilstein 7 IV 652.]

2,4'-Dibromoacetophenone Preparation Products And Raw materials

Raw materials

4'-Bromoacetophenone

Preparation Products

3-(4-BROMOPHENYL)ISOXAZOL-5-AMINE-->4-(4-BROMO-PHENYL)-1H-IMIDAZOLE-->2-(4-BROMOBENZOYL)-1-BENZOFURAN-5-CARBALDEHYDE-->2-(4-bromophenyl)morpholine-->2-Amino-4'-bromoacetophenone-->1-(4-bromophenyl)-2-chloroethan-1-one-->2-Thiazolecarboxylic acid,4-(4-bromophenyl)-,ethyl ester-->1-(4-Bromophenyl)-2-(4-methylpiperazin-1-yl)ethanone-->6-(4-BROMOPHENYL)-3-PHENYL-7H-[1,2,4]TRIAZOLO[3,4-B][1,3,4]THIADIAZINE-->4-(4-BROMOPHENYL)-2(3H)-THIAZOLONE HYDRAZONE

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