Products

6-Methoxy-2-naphthaldehyde

Product Introduction

6-Methoxy-2-naphthaldehyde Basic information

Product Name:	6-Methoxy-2-naphthaldehyde
Synonyms:	LABOTEST-BB LT01147524;ASINEX-REAG BAS 07663025;6-METHOXY-2-NAPHTHALDEHYDE;TIMTEC-BB SBB010060;6-methoxy-2-naphthalaldehyde;6-methoxynaphthalene-2-carbaldehyde;6-Methoxy-2-Naphtaldehyde;6-Methoxy-2-naphthaldehyde,99%
CAS:	3453-33-6
MF:	C12H10O2
MW:	186.21
EINECS:	222-377-2
Product Categories:	Building Blocks;C10-C12;Aromatic Aldehydes & Derivatives (substituted);Carbonyl Compounds;Chemical Synthesis;Organic Building Blocks;Aldehydes;C10 to C21;Carbonyl Compounds;1;bc0001
Mol File:	3453-33-6.mol

6-Methoxy-2-naphthaldehyde Chemical Properties

Melting point	81-84 °C(lit.)
Boiling point	196 °C / 10mmHg
density	1.169±0.06 g/cm3(Predicted)
vapor pressure	0.022Pa at 25℃
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
solubility	Chloroform (Slightly), Methanol (Slightly, Sonicated)
form	powder to crystal
color	White to Light yellow to Light orange
Water Solubility	150.1mg/L at 25℃
Sensitive	Air Sensitive
BRN	1945989
LogP	2.97 at 25℃
CAS DataBase Reference	3453-33-6(CAS DataBase Reference)

Safety Information

MSDS Information

6-Methoxy-2-naphthaldehyde Usage And Synthesis

Chemical Properties	yellow to beige-yellow crystals or crystalline
Uses	6-Methoxy-2-naphthaldehyde is used as a diagnostic reagent in tumor studies involving aldehyde dehydrogenase enzymes. In addition it is used in organic synthesis reactions forming fluorescent substrates for inhibition studies relating to hypertension and vascular inflammation. It is also used as intermediate of Nabumetone.
Uses	6-Methoxy-2-naphthaldehyde may be used in the preparation of the following 4-(6-methoxy-2-naphthyl)butan-2-one related compounds: 4-(6-methoxy-2-naphthyl)but-3-en-2-one 4-(6-methoxy-2-naphthyl)-3-methylbutan-2-one 5-(6-methoxy-2-naphthyl)pentan-3-one It may also be used in the synthesis of the following chalcone derivatives: (2E)-1-(2-hydroxyphenyl)-3-(6-methoxy-2-naphthyl)prop-2-en-1-one (2E)-1-(2-chloropyridin-4-yl)-3-(6-methoxy-2-naphthyl)prop-2-en-1-one (2E)-3-(6-methoxy-2-naphthyl)-1-pyridin-4-ylprop-2-en-1-one (2E)-1-(2,4-dichlorophenyl)-3-(6-methoxy-2-naphthyl)prop-2-en-1-one
Synthesis Reference(s)	The Journal of Organic Chemistry, 53, p. 4587, 1988 DOI: 10.1021/jo00254a035
General Description	6-Methoxy-2-naphthaldehyde can be prepared by reacting 2-bromo 6-methoxy naphthalene with triethylorthoformate via Grignard reaction. Its crystals belong to the orthorhombic space group, P212121 and shows excellent NLO (non-linear optical) property.
Flammability and Explosibility	Not classified

6-Methoxy-2-naphthaldehyde Preparation Products And Raw materials

Raw materials	Tetrahydrofuran-->Acetic acid-->N,N-Dimethylformamide-->Government regulation-->n-Butyllithium-->Tin-->2-Methoxynaphthalene
Preparation Products	6-Methoxy-2-vinylnaphthalene-->6-Hydroxy-2-naphthaldehyde-->6-Methoxy-2-Acetyl Naphthalene-->NABUMETONE RELATED COMPOUND A (15 MG) (1-(6-METHOXY-2-NAPHTHYL)-BUT-1-EN-3-ONE)-->(6-methoxynaphthalen-2-yl)methanamine-->2,2,2-TRIFLUORO-1-(6-METHOXY-NAPHTHALEN-2-YL)-ETHANONE