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Mol File:
90-00-6.mol
2-Ethylphenol Chemical Properties
Melting point
-18 °C (lit.)
Boiling point
195-197 °C (lit.)
density
1.037 g/mL at 25 °C (lit.)
refractive index
n20/D 1.536(lit.)
Fp
78 °C
storage temp.
Keep in dark place,Inert atmosphere,Room temperature
solubility
Chloroform (Slightly), Methanol (Slightly)
pka
pK1:10.2 (25°C)
form
clear liquid
color
Colorless to Light yellow
Water Solubility
insoluble
Merck
14,3839
BRN
1099397
Stability:
Stable. Combustible. Incompatible with acid chlorides, acid anhydrides, oxidizing agents.
LogP
2.470
CAS DataBase Reference
90-00-6(CAS DataBase Reference)
NIST Chemistry Reference
Phenol, 2-ethyl-(90-00-6)
EPA Substance Registry System
o-Ethylphenol (90-00-6)
Safety Information
Hazard Codes
Xn,Xi,C
Risk Statements
22-37/38-41-34-20/21/22
Safety Statements
36/37/39-45-26
RIDADR
UN 3145 8/PG 2
WGK Germany
3
RTECS
SL4025000
F
8
TSCA
Yes
HazardClass
8
PackingGroup
III
HS Code
29071900
Hazardous Substances Data
90-00-6(Hazardous Substances Data)
MSDS Information
Provider
Language
2-Ethylphenol
English
ACROS
English
SigmaAldrich
English
ALFA
English
2-Ethylphenol Usage And Synthesis
Chemical Properties
2-Ethylphenol is a colorless liquid. It is one of three isomeric ethylphenols. It has been used as a reagent for the synthesis of phenoxyacetic acid derivatives as novel free fatty acid receptor 1 agonists for the treatment of diabetes mellitus. 2-Ethylphenol has also been used in the preparation of aminoquinazoline-like toll receptor ligands and for potential immunotherapy.
Uses
2-Ethylphenol is used as a reagent in the synthesis of phenoxyacetic acid derivatives as novel free fatty acid receptor 1 agonists used in the treatment of diabetes. It is also used in the preparation of aminoquinazolines as Toll-like receptor 4 ligands and potential immunotherapeutics.
Definition
ChEBI: 2-Ethylphenol is a member of phenols.
Preparation
2-Ethylphenol is produced by ethylation of phenol using ethylene or ethanol in the presence of aluminium phenolate. It is a natural product found in Cichorium endivia, Saussurea involucrata, and other organisms with data available.
Safety Profile
Poison by intraperitoneal route. Moderately toxic by ingestion. Human toxic action similar to, but less severe than, that of phenol. Questionable carcinogen with experimental neoplastigenic data. When heated to decomposition it emits acrid smoke and irritating fumes. See also PHENOL
Purification Methods
Purify as for p-ethylphenol below. [Beilstein 6 H 470, 6 IV 3011.]
2-Ethylphenol Preparation Products And Raw materials
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